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Clinical
Experience : Dr. Santa Sabuj Das Worked
as a house physician for one year in the Department of Medicine at NRS Medical College and Hospital, Kolkata
and served as a postgraduate trainee in
the Department of Medicine at SSKM Hospital, Kolkata from 1993-1996.He
also worked
as a senior resident of the Department of Clinical Immunology at Sanjay
Gandhi Postgraduate Institute of Medical Education, Lucknow,India.
Research
Experience :
Dr.Santasabuj
Das started his carrer in basic research in 1997 as a research associate
of the Department of Cellular Immunology at Indian Institute of Chemical
Biology, Kolkata, India where he worked on leishmaniasis. He then joined
the Department of Clinical Immunology at Sanjay Gandhi Postgraduate
Institute of Medical Education, Lucknow, India and worked on the clinical
and basic sciences aspects of immune-mediated diseases. Subsequently, he
joined National Center for Biological Sciences at Bangalore, India as a
visiting postdoctoral fellow where his focus of research was to
investigate the role of Notch-Jagged signaling in cervical carcinogenesis.
He moved to USA in the year of 2000 to join the laboratory of Dr. Philip
N. Tsichlis at Kimmel Cancer Center, Thomas Jefferson University,
Philadelphia, Pennsylvania as a postdoctoral fellow where he worked on the
role of Tvl-1/RFXANK in the transcriptional regulation of MHC classII
molecules. He moved to
Boston, Massachusettes with Dr. Tsichlis who became the Jane
F. Desforges Professor of Hematology and Oncology
and the Director of Molecular Oncology Research Institute under Tufts
University. Dr. Das subsequently became a research associate in the same
laboratory. His research there focused on the role of Tpl2, an upstream
MAPK, in the pro- -inflammatory cytokine (TNF-a
and IL-1b)
induced signal transduction pathways. His work showed that Tpl2-mediates
the activation of MAPKinases and NF-kB
by TNF-a
and IL-1b-induced
signals in a cell type and stimulus specific manner and that both the
adaptor molecules TRAF2 and RIP-1 are required for transduction of TNF-a
signals by Tpl2.
Current
research interest:
: Currently, Dr.Das’s laboratory
focuses on exploring the molecular mechanisms of the immunomodulatory role
of cholera toxin. Although, cholera toxin has a well-recognized
immunomodulatory function that forms the basis of its extensive use as a
mucosal adjuvant to many vaccines, the precise mechanism for such function
remains unclear. Dr. Das’s laboratory plans to delineate the cytokine/chemokine
network responsible for immunomodulation by cholera toxin and the signal
transduction pathways that regulate this network. This will help in better
understanding of the pathogenesis of cholera and in designing better
vaccines against cholera and other mucosal pathogens.
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